Why Transparency is Non-Negotiable

In a high-stakes medical environment, you need to trust what you see. The shift toward crystal-clear PVC tubing isn’t an aesthetic choice—it’s a safety protocol.

Clear tubing gives clinicians a window into the process, allowing them to visually monitor flow in real-time. It means spotting an air bubble, a blockage, or a contaminant before it can become a problem. This visibility is vital for:

• IV Therapy: Instantly verifying the smooth delivery of hydration and medication.

• Dialysis: Monitoring blood and fluid exchange with absolute clarity.

• Surgical Suction: giving surgeons immediate visual feedback during fluid removal.

• Manufacturing: Supporting sterile, large‑scale production with clear tubing that ensures quality and compliance.

Maximizing Liposuction Efficiency: The Dual-Connection Advantage

Time is truly a critical factor in the operating room. Brevet’s Parallel Y is engineered to solve one of the most common bottlenecks in liposuction: instrument exchange downtime.

By using a dual-connection port, surgeons can gain significant workflow advantages such as:

• Seamless Instrument Transition: Surgeons can connect two different cannula sizes (e.g. larger diameter for debulking and a finer gauge for contouring) simultaneously. This provides a means for rapid switching between the tools without having to stop to disconnect tubing, or break the suction seal.
• Continuous Suction Pressure: The parallel geometry ensures that even if one line is momentarily obstructed by tissue, the secondary path remains active, and this allows for maintaining consistent negative pressure and thus, preventing pump strain.
• Simultaneous Aspiration: For larger surface areas, the dual-port design effectively doubles the intake capacity. This allows for a smoother, faster removal of adipose tissue, with less physical exertion for the surgeon during the procedure.

Superior Fluid Dynamics

Unlike standard Y-connectors that create turbulence at the junction point, Brevet’s Parallel Y is designed for laminar flow.

• Parallel geometry ensures balanced flow across both channels.
• Smooth internal surfaces minimize shear stress on harvested fat cells. This is a critical factor for maximizing cell viability during fat grafting and also transfer procedures.

The Strategic Power of Single-Use Technology (SUT)

In an era where infection control is truly paramount, Brevet’s Parallel Y connector is able to leverage the power of Single-Use Technology to protect both the patient and the practice! Moving away from reusable metal connectors offers real and distinct advantages:

1. Elimination of Cross-Contamination: Even with rigorous autoclaving, reusable connectors can develop microscopic scratches that harbor bio-burden. Our single-use PVC connectors guarantee a pristine, sterile fluid path for every single patient, eliminating the risk of patient-to-patient transmission.
2. Operational Efficiency: SUT eliminates the labor costs, chemical usage, and documentation burden associated with cleaning and sterilizing reusable equipment. Your team will be able to focus on patient care more, and not as much on instrument processing.
3. Material Integrity: Repeated sterilization degrades materials over time. With a single-use connector, you’re guaranteed the exact same flexibility, seal integrity, and also the performance in every surgery, with no risk of material fatigue or also cracking issues.

Custom Manufacturing for Surgical Facilities

Every clinic has its own workflow and Brevet meets you there. We offer custom molding for:

• Port diameters and lengths
• Color-coded channels for easy identification
• Private-label packaging
• Batch traceability and sterile certification

Whether you’re running a high-volume aesthetic center or a boutique surgical suite, our team can tailor the Parallel Y to your exact, specific standards and needs!

Ready to Customize Your Connector?

Brevet supports plastic surgeons across North & South America and Europe with precision-molded fluid components built for clean flow and confident care!

Upstream: Protecting Delicate Life

The upstream phase is all about nurturing growth. Whether you are working with mammalian cells or microbial fermentation, the environment really does have to be perfect.

Brevet’s connectors are designed with smooth internal geometry specifically to reduce shear stress. Cells are fragile and any turbulent flow through a poorly designed connector can damage them. This then will ruin viability before you even get started. Our connectors ensure that nutrient delivery and aseptic sampling happen gently, keeping the focus on cell health instead of attention on equipment troubleshooting.

Aseptic vs. Sterile: The Crucial Distinction

It is important to know that ‘aseptic’ and ‘sterile’ are not the same thing. ‘Sterile’ is a reactive term; it means a product was made and then treated to eliminate all microorganisms, much like cleaning up a spill after it happens. ‘Aseptic’, on the other hand, is a proactive philosophy and it means a product was designed, manufactured, and packaged in a way that prevents it from ever being exposed to contaminants from the very start. This is like engineering a cup that never spills at all. This proactive mindset is essential for critical fluid components, like Brevet’s connectors and adapters, as it’s the only way to ensure a pristine fluid path and protect patient safety.

Why Every Detail Matters: From Dead Space to Biofilms

In sensitive fluid paths, even microscopic flaws can be catastrophic. A tiny “dead space” or a rough surface within a connector can become a breeding ground for microbes, forming biofilms that contaminate the entire system.

This is why aseptic assurance is vital:

• Medtech & Biopharma: Essential for IVs, drug delivery, and diagnostics to prevent infection and ensure accurate results.

• Cosmetics: Critical for high-purity formulations, protecting product integrity and consumer safety.

• Veterinary Care: Ensures safe fluid delivery for animal patients, mirroring human standards.

• Industrial and Fluid Fill Lines: Ensure safe consumer fluids are delivered and injected into their portable form factors.

Brevet’s Engineering for Aseptic Excellence

You can’t “inspect” aseptic quality into a product; you have to design and build it in. At Brevet, it’s foundational:

• Controlled Manufacturing: ISO-certified cleanrooms use precision, all-electric injection molding in meticulously controlled environments. Products are “born clean” depending on the select product being manufactured.

• Smart Design: Our engineers specialize in Design for Aseptic Manufacturing.

• No Dead Space: Brevet components ensure smooth, laminar flow, eliminating hidden crevices where microbes can flourish.

• Immaculate Surfaces: We engineer mirror-smooth internal surfaces, denying bacteria a foothold.

• Pure Materials: We exclusively use premium, medical-grade, and RoHS3-compliant materials, preventing leaching and fluid contamination.

• Your Trusted Partner (Contract Manufacturing): For innovators seeking a reliable manufacturing partner, Brevet steps in. As a contract manufacturer, we don’t just supply parts, we supply the entire aseptic assurance process depending on the products needed. 

Assurance You Can Trust, Built By Brevet

Aseptic assurance isn’t just a feature, it truly is a commitment to uncompromising safety. It’s the guarantee that every component from Brevet upholds the highest standards from conception to patient  and client application.

Procurement Checklist: What to Look For

When selecting critical fluid components, how can you ensure true aseptic assurance? Download our visual checklist for procurement teams—highlighting key features and questions to ensure optimal aseptic integrity in fluid systems.

So what is RoHS 3, really?

RoHS stands for Restriction of Hazardous Substances. The “3” means it’s the latest version — updated to include four additional phthalates alongside the original six restricted substances. These are chemicals you don’t want in your supply chain. Think lead, mercury, cadmium… plus DEHP, BBP, DBP, and DIBP. We know, it’s a mouthful.)

Brevet’s connectors don’t use any of those. We’ve always been picky about materials — not just for performance, but for safety. RoHS 3 just makes that official.

What RoHS 3 Restricts

RoHS 3 limits the use of 10 hazardous substances, including:

• Lead
• Mercury
• Cadmium
• Hexavalent Chromium
• Polybrominated Biphenyls (PBB)
• Polybrominated Diphenyl Ethers (PBDE)
• Four phthalates: DEHP, BBP, DBP, DIBP

 Why it matters even if your product isn’t electronic

RoHS 3 isn’t just for gadgets. It also applies to any product that may also contain restricted substances as well. That includes plastics, coatings, adhesives and even packaging. And if you’re manufacturing in California, or shipping globally, RoHS 3 compliance can make or break your approvals.

California’s regulations are actually already aligned with RoHS 3 in many ways. So being compliant now means you’re ahead of the curve. No scrambling later. No last-minute substitutions. Just clean, trusted components from the start.

Brevet’s Commitment to Clean Materials

From perfusion adapters to Y-connectors, Brevet’s components are molded with precision and transparency — both literally and ethically. We don’t use restricted substances, and we’re proud to align with RoHS 3 and California’s future-focused standards.

So what’s a reducer?

It’s a sleek, clear connector that gently narrows the flow from larger tubing to smaller tubing. Think of it like a funnel and built for high-volume production.

Brevet’s polycarbonate reducers are crystal-clear, strong, and RoHS 3 compliant. They’re designed to keep things moving smoothly, especially in single-use systems where hygiene and precision matter most.

Why do cosmetics love them?

Because reducers help prevent splashes, spills, and overfills. They keep the flow steady and clean, which means less mess and more consistency — whether you’re filling 10 bottles or 10,000.

They’re perfect for:

• Lotion and serum filling lines
• Cosmetics such as foundations
• Creams and emulsions
• Single-use manufacturing setups
• Any process that needs a gentle, controlled transition

The beauty of it all

Brevet’s reducers don’t just work — they work beautifully. They’re part of the quiet choreography that turns raw ingredients into polished products. And while they may not get the spotlight, they’re essential to the performance.

So next time you swipe on a serum or smooth on a cream, remember that there’s a little connector behind the scenes making it all possible.

So What’s the Deal with Traditional Y Connectors?

Most Y connectors out there force fluid into sharp angles, which can cause turbulence, backpressure, and uneven distribution.

The Parallel Fix

Brevet’s Parallel Y Connector takes a different approach. Instead of merging lines at a steep angle, the two upper ports run side-by-side, parallel, so fluid enters and exits with way less resistance.

Here’s what that means:

• You get smoother, more laminar flow
• Pressure stays even across both arms
• The relatively clear PVC lets you actually see what’s going on
• Internal surfaces are smooth, so clogs are less likely

Where It Really Helps

Whether you’re working in a lab, a clinic, or somewhere in between, the Parallel Y makes multi-line setups easier and cleaner.

• Biopharma: Dual reagent delivery or waste routing
• Veterinary: CRI setups with syringe drivers
• Clinical: Dual-line suction or irrigation systems

Geometry That Just Feels Right

It’s not just functional it’s actually kind of beautiful. The symmetry feels calm, the transparency builds trust, and the flow is just… nice. It’s a connector that gets the job done without making a fuss.

The Advancements in the Cardiac Sector

Cardiac procedures, from diagnostic angiograms to complex interventional cardiology and open-heart surgeries, rely on a vast array of specialized equipment. Recent years have witnessed remarkable progress, including:

• Minimally Invasive Techniques: Procedures like TAVR (Transcatheter Aortic Valve Replacement) and MitraClip have revolutionized valve repair and replacement, reducing patient recovery times and risks.
• Advanced Diagnostics: High-resolution imaging and real-time physiological monitoring provide unprecedented insights into cardiac function.
• Personalized Medicine: Tailored treatments are becoming more common, requiring adaptable and highly precise tools.

These advancements, while immensely beneficial, also introduce heightened complexities and an imperative for absolute sterility to prevent healthcare-associated infections (HAIs), which can be particularly devastating for cardiac patients.

Why Sterile Single-Use is the Future

Traditional reusable devices, while effective, come with inherent challenges: the need for rigorous cleaning, disinfection, and sterilization protocols; the risk of cross-contamination; and the potential for wear and tear affecting device performance. Single-use technology elegantly circumvents these issues, offering undeniable advantages:

• Guaranteed Sterility: Each device is individually packaged and pre-sterilized, eliminating the risk of reprocessing failures and ensuring a pristine device for every patient.
• Enhanced Patient Safety: By removing reprocessing variables, SUT significantly reduces the risk of HAIs and potential bioburden.
• Procedural Efficiency: Single-use components streamline setup, eliminate sterilization cycles, and reduce turnaround times, allowing for more efficient use of operating room capacity.
• Consistent Performance: Every device is new, ensuring optimal performance characteristics and eliminating concerns about material fatigue or residual contamination from prior use.
• Reduced Costs (Long-Term): While initial per-item costs might seem higher, SUT often leads to significant savings by eliminating reprocessing labor, chemicals, utilities, and the capital expenditure of sterilization equipment, not to mention the avoided costs associated with HAIs.

Beyond Standard Solutions
Brevet’s Custom Contract Manufacturing for Cardiac Applications

While our standard line of single-use components offers robust solutions for many cardiac procedures, Brevet’s true strength lies in our comprehensive custom contract manufacturing capabilities. We understand that innovative cardiac devices and complex bioprocessing systems often require highly specialized fluidic components that simply don’t exist off-the-shelf.

Our expert engineering and manufacturing teams collaborate closely with clients to design, develop, and produce bespoke connectors, adapters, and other critical fluid path components. From initial concept and material selection to rapid prototyping, mold development, and high-volume sterile production, Brevet acts as an extension of your own R&D and manufacturing departments.

This custom approach ensures that:

• Precise Fit & Function: Components are engineered to perfectly integrate with your unique device or system, optimizing performance and minimizing potential failure points.
• Material Compatibility: We select materials, such as specific grades of polycarbonate or other biocompatible polymers, that meet the exact chemical resistance, pressure, and temperature requirements of your specific application and sterilization methods (e.g., gamma irradiation, E-beam).
• Accelerated Development: Our agile development process helps shorten your time-to-market for new cardiac devices and therapies.
• Scalable Production: Whether you need pilot-scale batches or high-volume production, our facilities are equipped to deliver consistent quality and quantity, all under stringent cleanroom conditions (e.g., ISO Class 7 or 8) and adhering to GMP standards.
• Risk Mitigation: Leveraging our deep expertise in sterile single-use manufacturing for critical medical applications, we help you mitigate risks associated with design, validation, and regulatory compliance, particularly for devices used in direct patient contact or sterile fluid transfer within cardiac procedures.

By partnering with Brevet for custom single-use component manufacturing, innovators in the cardiac sector can focus on their core competencies, confident that their crucial fluidic connections are engineered for excellence and guaranteed for sterility.

The Lab Bench: Where Innovation Begins with Agility

In the early stages of pharmaceutical R&D, flexibility and rapid iteration are paramount. Scientists are experimenting with new cell lines, optimizing media formulations, and exploring novel bioprocesses. This is where SUT offers an immediate and profound advantage:

• Rapid Prototyping: Single-use systems allow researchers to quickly set up, run, and dismantle experiments without the time-consuming burden of cleaning and sterilizing traditional equipment. This means more experiments can be conducted in less time, accelerating the discovery phase.
• Reduced Cross-Contamination: With disposable components, the risk of carryover contamination between different experiments or cell lines is virtually eliminated, ensuring data integrity and reliable results.
• Cost-Effective Experimentation: For small-scale runs, using single-use bioreactors and custom fluid paths (built with components like Brevet’s Y-connectors and straight connectors) is often more economical than dedicating and sterilizing large, reusable equipment.
  
  
  

This agile environment, fueled by sterile fluid transfer solutions, directly translates to faster insights and a quicker transition of promising candidates to the next development phase.

Scaling Up for Success: Bridging the Gap to Production

The true test of a drug candidate comes during scale-up, moving from small lab batches to larger volumes required for clinical trials and eventually commercial production. This phase traditionally presents significant hurdles, but SUT, supported by expertly engineered components, smooths the transition:

• Seamless Scale-Up: Single-use bioreactors and fluid manifolds can be easily scaled up in size, minimizing the need for extensive re-validation and re-engineering often associated with transitioning to larger stainless-steel systems. Brevet’s ability to manufacture custom fluid manifolds and polycarbonate connectors ensures consistent, scalable solutions.
• Enhanced Production Flexibility: Bioprocess scale-up SUT allows manufacturing facilities to produce multiple products or different batches in quick succession, significantly reducing downtime. This flexibility is crucial for CDMOs (Contract Development and Manufacturing Organizations) and companies managing diverse pipelines.
• Reduced Capital Expenditure: Investing in large, fixed stainless-steel infrastructure can be prohibitive. SUT, by contrast, offers a lower upfront capital investment, making biopharmaceutical manufacturing more accessible and adaptable.

Components like Brevet’s 60-degree Y-Connectors play a critical role here, enabling precise and sterile diversion or combination of fluids across increasingly complex bioprocess scale-up SUT designs.

The Brevet Advantage: Precision in Every Path

Brevet’s expertise is perfectly aligned with the demands of accelerating drug development through Single-Use Technology. Our commitment to precision plastic components means we provide the reliable foundation for your fluid pathways:

• Custom Fluid Path Engineering: We don’t just supply parts; we partner with you to design and manufacture bespoke custom single-use connectors, fluid manifolds, perfusion adapters, and custom syringes that integrate seamlessly into your unique bioprocess.
• Material Science Mastery: Utilizing USP Class VI-compliant polycarbonate and other medical-grade plastics, we ensure biocompatibility, chemical resistance, and sterilizability—non-negotiable attributes for sterile manufacturing.
• Precision Injection Molding: Our advanced plastic contract manufacturing processes guarantee every component is molded to exact specifications, ensuring leak-proof performance and the structural integrity vital for bioprocess scale-up SUT.

The Future of Medicine, Accelerated by SUT

The rapid growth of cell and gene therapy manufacturing and the drive for more efficient vaccine production underscore the critical importance of SUT. By continually advancing in single-use fluid management, Brevet empowers pharmaceutical companies to innovate faster, scale more effectively, and ultimately bring life-saving and life-improving therapies to patients around the world with unprecedented speed and safety.

Ready to leverage the full potential of Single-Use Technology for your drug development pipeline? Contact Brevet today to discuss your custom SUT component needs and accelerate your journey from lab bench to large-scale success.

Revolutionizing Equine Medicine with Single-Use Technology

The world of equine medicine is constantly evolving, with new technologies and techniques emerging to improve the health and well-being of horses. A significant leap forward is happening in the fluid component market, where advancements in single-use technology are fundamentally changing how veterinarians approach a variety of surgical and medical procedures. Brevet specializes in contract manufacturing of custom-designed fluid components, and this isn’t just a trend—it’s the future of safe and efficient large animal care.

The Challenge of Size and Scale in Equine Surgery

Unlike human patients, horses come in a vast range of sizes, from a small pony to a large draft horse. This anatomical diversity presents a unique challenge for veterinary surgeons. A surgical instrument or component designed for a 1,000-pound Quarter Horse may be completely unsuitable for a 2,000-pound Clydesdale, or a delicate miniature horse. This is particularly true for procedures requiring precise fluid delivery, such as joint flushing or regional limb perfusion.

Research shows that even common surgical tools, like those used for laparoscopy, come in a variety of lengths and diameters to accommodate a horse’s size and the specific area of the body being treated. Reusable components, while a long-standing practice, can present risks. The extensive cleaning and sterilization required to ensure they are free of contaminants can be time-consuming and, if not done perfectly, can lead to the risk of cross-contamination and post-operative infections. This is where single-use technology, made from the highest quality medical-grade materials, offers a powerful solution.

Brevet’s custom perfusion adapter stands as a prime example of this innovative approach. Designed to address the unique anatomical challenges of a horse, this component can be tailored to a specific size or shape, ensuring a perfect, leak-proof seal during critical procedures like joint flushes. This precision is essential for delivering medicated fluids exactly where they are needed, ensuring the best possible outcome for the patient.

Why Single-Use Technology (SUT) is a Game-Changer

Brevet’s commitment to designing and manufacturing fluid components for the equine market is built on three core pillars:

1. Safety: Single-use components eliminate the risk of cross-contamination, ensuring a sterile product for every patient, every time.
2. Quality: By using only the highest quality medical-grade materials, Brevet guarantees that its components are durable, reliable, and safe for use in sensitive surgical environments.
3. Efficiency: For veterinary clinics, single-use technology streamlines workflows. There is no need for time-consuming cleaning and sterilization protocols, allowing staff to focus on patient care.

As the equine market continues to demand safer, more precise, and more reliable medical solutions, Brevet is leading the way. The shift toward custom-designed, single-use fluid components is not just a passing trend—it’s a critical step forward in ensuring the best possible outcomes for our amazing large animal companions.