Accelerating Drug Development with Single-Use Fluid Paths

Lab Bench to Large Scale

The journey of a new pharmaceutical drug, from initial discovery in the lab to mass production that impacts patient lives, is one of the most complex and critical endeavors known to science. Every step requires meticulous precision, rigorous quality control, and the ability to adapt. In this dynamic landscape, Single-Use Technology (SUT) has emerged as a game-changer, fundamentally transforming how drug development is accelerated. At Brevet, we provide the precision plastic components and custom single-use connectors that empower biopharma companies to navigate this journey with unprecedented speed, safety, and efficiency.

The Lab Bench: Where Innovation Begins with Agility

In the early stages of pharmaceutical R&D, flexibility and rapid iteration are paramount. Scientists are experimenting with new cell lines, optimizing media formulations, and exploring novel bioprocesses. This is where SUT offers an immediate and profound advantage:

Rapid Prototyping: Single-use systems allow researchers to quickly set up, run, and dismantle experiments without the time-consuming burden of cleaning and sterilizing traditional equipment. This means more experiments can be conducted in less time, accelerating the discovery phase.
Reduced Cross-Contamination: With disposable components, the risk of carryover contamination between different experiments or cell lines is virtually eliminated, ensuring data integrity and reliable results.
Cost-Effective Experimentation: For small-scale runs, using single-use bioreactors and custom fluid paths (built with components like Brevet’s Y-connectors and straight connectors) is often more economical than dedicating and sterilizing large, reusable equipment.

This agile environment, fueled by sterile fluid transfer solutions, directly translates to faster insights and a quicker transition of promising candidates to the next development phase.

Scaling Up for Success: Bridging the Gap to Production

The true test of a drug candidate comes during scale-up, moving from small lab batches to larger volumes required for clinical trials and eventually commercial production. This phase traditionally presents significant hurdles, but SUT, supported by expertly engineered components, smooths the transition:

Seamless Scale-Up: Single-use bioreactors and fluid manifolds can be easily scaled up in size, minimizing the need for extensive re-validation and re-engineering often associated with transitioning to larger stainless-steel systems. Brevet’s ability to manufacture custom fluid manifolds and polycarbonate connectors ensures consistent, scalable solutions.
Enhanced Production Flexibility: Bioprocess scale-up SUT allows manufacturing facilities to produce multiple products or different batches in quick succession, significantly reducing downtime. This flexibility is crucial for CDMOs (Contract Development and Manufacturing Organizations) and companies managing diverse pipelines.
Reduced Capital Expenditure: Investing in large, fixed stainless-steel infrastructure can be prohibitive. SUT, by contrast, offers a lower upfront capital investment, making biopharmaceutical manufacturing more accessible and adaptable.

Components like Brevet’s 60-degree Y-Connectors play a critical role here, enabling precise and sterile diversion or combination of fluids across increasingly complex bioprocess scale-up SUT designs.

The Brevet Advantage: Precision in Every Path

Brevet’s expertise is perfectly aligned with the demands of accelerating drug development through Single-Use Technology. Our commitment to precision plastic components means we provide the reliable foundation for your fluid pathways:

Custom Fluid Path Engineering: We don’t just supply parts; we partner with you to design and manufacture bespoke custom single-use connectors, fluid manifolds, perfusion adapters, and custom syringes that integrate seamlessly into your unique bioprocess.
Material Science Mastery: Utilizing USP Class VI-compliant polycarbonate and other medical-grade plastics, we ensure biocompatibility, chemical resistance, and sterilizability—non-negotiable attributes for sterile manufacturing.
Precision Injection Molding: Our advanced plastic contract manufacturing processes guarantee every component is molded to exact specifications, ensuring leak-proof performance and the structural integrity vital for bioprocess scale-up SUT.

The Future of Medicine, Accelerated by SUT

The rapid growth of cell and gene therapy manufacturing and the drive for more efficient vaccine production underscore the critical importance of SUT. By continually advancing in single-use fluid management, Brevet empowers pharmaceutical companies to innovate faster, scale more effectively, and ultimately bring life-saving and life-improving therapies to patients around the world with unprecedented speed and safety.

Ready to leverage the full potential of Single-Use Technology for your drug development pipeline? Contact Brevet today to discuss your custom SUT component needs and accelerate your journey from lab bench to large-scale success.